uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Alveolar accumulation/concentration of nitrogen during apneic oxygenation with arteriovenous carbon dioxide removal
Show others and affiliations
2010 (English)In: ASAIO journal (1992), ISSN 1058-2916, E-ISSN 1538-943X, Vol. 56, no 1, 30-34 p.Article in journal (Refereed) Published
Abstract [en]

In a model of acute lung injury (ALI), previously, we have shown that apneic oxygenation, using an inspiratory O2 fraction (FiO2) of 1.0 combined with extracorporeal arteriovenous CO2 removal (AO-AVCR) maintains adequate arterial O2 and CO2 levels for a prolonged period. However, it is important that FiO2 lower than 1.0 can be used to avoid possible pulmonary oxygen toxicity. In preliminary studies, arterial oxygenation decreased to extreme low levels, when FiO2 <1 was used in apneic oxygenation. We assumed that this was caused either by alveolar accumulation/concentration of N2 or by absorption atelectasis. In four anesthetized and mechanically ventilated pigs, mild lung injury was induced. After a lung recruitment maneuver, we initiated two 20-minute periods of AO-AVCR with FiO2 of 1 and 0.5, respectively. By using FiO2 = 1, PaO2 remained above 300 mm Hg. At the end of the period, the alveolar O2 fraction (FAO2) was 0.89 (0.88-0.89; median and ranges). With FiO2 = 0.5, PaO2 decreased 90% compared with baseline values and FAO2 decreased to 0.07 (0.06-0.07). No atelectasis was visible on computed tomography after either period, and we, therefore, conclude that the alveolar hypoxia was caused by the alveolar N2 accumulation/concentration and subsequently by the O2 depletion.

Place, publisher, year, edition, pages
2010. Vol. 56, no 1, 30-34 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-114155DOI: 10.1097/MAT.0b013e3181c4e935ISI: 000273651300006PubMedID: 20038832OAI: oai:DiVA.org:uu-114155DiVA: diva2:293248
Available from: 2010-02-11 Created: 2010-02-11 Last updated: 2010-12-21Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Anaesthesiology and Intensive Care
In the same journal
ASAIO journal (1992)
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 165 hits
ReferencesLink to record
Permanent link

Direct link