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Animal models of amyloid-β-related pathologies in Alzheimer’s disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.ORCID iD: 0000-0003-3117-5367
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2010 (English)In: The FEBS Journal, ISSN 1742-464X, E-ISSN 1742-4658, Vol. 277, no 6, 1389-1409 p.Article, review/survey (Refereed) Published
Abstract [en]

In the early 1990s, breakthrough discoveries on the genetics of Alzheimer's disease led to the identification of missense mutations in the amyloid-beta precursor protein gene. Research findings quickly followed, giving insights into molecular pathogenesis and possibilities for the development of new types of animal models. The complete toolbox of transgenic techniques, including pronuclear oocyte injection and homologous recombination, has been applied in the Alzheimer's disease field, to produce overexpressors, knockouts, knockins and regulatable transgenics. Transgenic models have dramatically advanced our understanding of pathogenic mechanisms and allowed therapeutic approaches to be tested. Following a brief introduction to Alzheimer's disease, various nontransgenic and transgenic animal models are described in terms of their values and limitations with respect to pathogenic, therapeutic and functional understandings of the human disease.

Place, publisher, year, edition, pages
2010. Vol. 277, no 6, 1389-1409 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-114200DOI: 10.1111/j.1742-4658.2010.07564.xISI: 000274923100006PubMedID: 20136653OAI: oai:DiVA.org:uu-114200DiVA: diva2:293445
Available from: 2010-02-11 Created: 2010-02-11 Last updated: 2017-12-12Bibliographically approved

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Gumucio, AstridO'Callaghan, PaulLannfelt, Lars

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