Premixed acidic calcium phosphate cement: characterization of strength and microstructure
2010 (English)In: Journal of biomedical materials research. Part B, Applied biomaterials, ISSN 1552-4973, Vol. 93B, no 2, 436-441 p.Article in journal (Refereed) Published
By using a premixed calcium phosphate cement (CPC), the handling properties of the cement are drastically improved, which is a challenge for traditional injectable CPCs. Previously premixed cements have been based on apatite cements In this article, acidic cement has been developed and evaluated Monocalcium phosphate monohydrate and beta-tricalcium phosphate were mixed with glycerol to form a paste As the paste does not contain water, no setting reaction starts and thus the working time is indefinite Powder/liquid ratios (P/L) of 2 25, 3 5 and 475 were evaluated Setting time (ST) and compressive strength (CS) were measured after 1 day, 1 week and 4 weeks in phosphate buffered saline (PBS) solution, and the corresponding microstructure was evaluated using electron microscopy and X-ray diffraction The ST started when the cements were placed in PBS and ranged from 28 to 75 min, higher P/L gave a lower ST Higher P/L also gave a higher CS, which ranged from 2 to 16 MPa The microstructure mainly consisted of monetite, 1-5 mu m in grain size After 4 weeks in PBS, the strength increased As acidic cements are resorbed faster in vivo, this cement should allow faster bone regeneration than apatitic cements Premixed cements show a great handling benefit when compared with normal CPCs and can be formulated with similar ST and mechanical properties.
Place, publisher, year, edition, pages
2010. Vol. 93B, no 2, 436-441 p.
Engineering and Technology
IdentifiersURN: urn:nbn:se:uu:diva-114484DOI: 10.1002/jbm.b.31600ISI: 000276715800018OAI: oai:DiVA.org:uu-114484DiVA: diva2:294236