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Premixed acidic calcium phosphate cement: characterization of strength and microstructure
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
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2010 (English)In: Journal of biomedical materials research. Part B, Applied biomaterials, ISSN 1552-4973, Vol. 93B, no 2, 436-441 p.Article in journal (Refereed) Published
Abstract [en]

By using a premixed calcium phosphate cement (CPC), the handling properties of the cement are drastically improved, which is a challenge for traditional injectable CPCs. Previously premixed cements have been based on apatite cements In this article, acidic cement has been developed and evaluated Monocalcium phosphate monohydrate and beta-tricalcium phosphate were mixed with glycerol to form a paste As the paste does not contain water, no setting reaction starts and thus the working time is indefinite Powder/liquid ratios (P/L) of 2 25, 3 5 and 475 were evaluated Setting time (ST) and compressive strength (CS) were measured after 1 day, 1 week and 4 weeks in phosphate buffered saline (PBS) solution, and the corresponding microstructure was evaluated using electron microscopy and X-ray diffraction The ST started when the cements were placed in PBS and ranged from 28 to 75 min, higher P/L gave a lower ST Higher P/L also gave a higher CS, which ranged from 2 to 16 MPa The microstructure mainly consisted of monetite, 1-5 mu m in grain size After 4 weeks in PBS, the strength increased As acidic cements are resorbed faster in vivo, this cement should allow faster bone regeneration than apatitic cements Premixed cements show a great handling benefit when compared with normal CPCs and can be formulated with similar ST and mechanical properties.

Place, publisher, year, edition, pages
2010. Vol. 93B, no 2, 436-441 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-114484DOI: 10.1002/jbm.b.31600ISI: 000276715800018OAI: oai:DiVA.org:uu-114484DiVA: diva2:294236
Available from: 2010-02-16 Created: 2010-02-16 Last updated: 2016-04-19Bibliographically approved
In thesis
1. Premixed Acidic Calcium Phosphate Cements
Open this publication in new window or tab >>Premixed Acidic Calcium Phosphate Cements
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Calcium phosphate cements are used in medicine to fill bone defects or give support to screws and plates in fracture fixation. The cements are formed via mixing a powder with water and the mixture harden through a dissolution-precipitation reaction. Today the cement mixing is performed in the operating room and consists of several complicated steps that need to be performed under sterile conditions. This renders the mixing a risk factor, potentially leading to harm for the patient e.g. unsatisfactory healing or infection. To reduce this risk, premixed cements have been developed using glycerol as mixing liquid. The premixed cement sets when it is exposed to body liquids. Therefore, premixed cement can be delivered to the operating room in prefilled syringes ready for use, thus eliminating the mixing step.

The aim of this thesis is to describe differences between premixed and water-mixed cements and their advantages and drawbacks. The differences will be discussed based on results obtained from bench testing of specific cement properties as function of cement formulations as well as in vitro and in vivo studies.

Several cement formulations were evaluated e.g. the influence of powder to liquid ratio (P/L), powder particle size and addition of water on key properties. The results showed that premixed cements have excellent handling properties and have mechanical properties similar to water-based cements. Both P/L and particle size can be used to control these properties. It was shown that small amounts of water improve certain cement properties while dry raw materials were important for long shelf life. To better understand the setting of premixed cements new methods for evaluating working time and setting of premixed cements were developed. In vivo studies showed that the formulations developed in this thesis are biocompatible, resorbable and show good tissue response in bone.

This thesis concludes, that the premixed cements are a promising biomaterial with excellent handling properties and good biological response. The most important challenge for the premixed cements, in order to become commercially successful, is to obtain clinically relevant setting time and shelf life simultaneously. An increasing use of premixed cements in the clinics should shorten operation times and reduce infection rates to the benefit of both patients and medical staff.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2012. 61 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 904
Keyword
monetite, brushite, bone void filler, injecatilbity, in vivo, in vitro
National Category
Biomaterials Science Ceramics
Identifiers
urn:nbn:se:uu:diva-168650 (URN)978-91-554-8285-5 (ISBN)
Public defence
2012-03-29, Å2001, Ångstrsömslaboratoriet, Lägerhyddsvägen 1, Uppsala, 10:15 (English)
Opponent
Supervisors
Available from: 2012-03-08 Created: 2012-02-14 Last updated: 2013-04-08Bibliographically approved

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Åberg, JonasEngqvist, Håkan

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