TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia
2011 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 35, no 2, 272-274 p.Article in journal (Refereed) Published
TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n= 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression.
Place, publisher, year, edition, pages
2011. Vol. 35, no 2, 272-274 p.
Chronic lymphocytic leukemia, TP53 mutation, 17p-deletion, overall survival, time to treatment
Medical and Health Sciences
Research subject Medical Genetics; Molecular Genetics; Molecular Biology
IdentifiersURN: urn:nbn:se:uu:diva-115555DOI: 10.1016/j.leukres.2010.08.023ISI: 000286460200024PubMedID: 20870288OAI: oai:DiVA.org:uu-115555DiVA: diva2:295773