Variation in STAT4 is associated with systemic lupus erythematosus in a Finnish family cohort
2010 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 69, no 5, 883-886 p.Article in journal (Refereed) Published
To investigate if 10 single nucleotide polymorphisms (SNPs) and haplotypes in the STAT4 gene, previously associated with SLE in a Swedish case-control cohort, also are associated with SLE risk in a Finnish SLE family cohort.
Genotyping was performed in 192 Finnish families, with 237 affected individuals and their healthy relatives, using the SNPstream genotyping system.
TDT analysis provided the strongest signal of association for two linked SNPs; rs7582694 (P-value = 0.002, OR = 2.57) and rs10181656 (P-value = 0.001, OR = 2.53). We further performed haplotype association analysis using a sliding window approach which showed that the strongest association signal originates from SNPs in intron 3 of STAT4.
Our results provide evidence that the main association signal for STAT4 with SLE previously reported in Caucasians is the same in the Finnish population. This is the first study that confirms the association of STAT4 with SLE in a family cohort.
Place, publisher, year, edition, pages
2010. Vol. 69, no 5, 883-886 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-117769DOI: 10.1136/ard.2009.112284ISI: 000276982300021PubMedID: 19717398OAI: oai:DiVA.org:uu-117769DiVA: diva2:298360
De två första författarna delar förstaförfattarskapet2010-02-222010-02-222013-03-06Bibliographically approved