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Assisted assembly: how to improve a de novo genome assembly by using related species
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2009 (English)In: Genome Biology, ISSN 1465-6906, E-ISSN 1474-760X, Vol. 10, no 8, R88- p.Article in journal (Refereed) Published
Abstract [en]

We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.

Place, publisher, year, edition, pages
2009. Vol. 10, no 8, R88- p.
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Biological Sciences
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URN: urn:nbn:se:uu:diva-119535DOI: 10.1186/gb-2009-10-8-r88ISI: 000269672900014PubMedID: 19712469OAI: oai:DiVA.org:uu-119535DiVA: diva2:300407
Available from: 2010-02-26 Created: 2010-02-26 Last updated: 2017-12-12Bibliographically approved

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Lindblad-Toh, Kerstin

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