uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Assisted assembly: how to improve a de novo genome assembly by using related species
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2009 (English)In: Genome Biology, ISSN 1465-6906, E-ISSN 1465-6914, Vol. 10, no 8, R88- p.Article in journal (Refereed) Published
Abstract [en]

We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.

Place, publisher, year, edition, pages
2009. Vol. 10, no 8, R88- p.
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-119535DOI: 10.1186/gb-2009-10-8-r88ISI: 000269672900014PubMedID: 19712469OAI: oai:DiVA.org:uu-119535DiVA: diva2:300407
Available from: 2010-02-26 Created: 2010-02-26 Last updated: 2011-06-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lindblad-Toh, Kerstin
By organisation
Department of Medical Biochemistry and Microbiology
In the same journal
Genome Biology
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 266 hits
ReferencesLink to record
Permanent link

Direct link