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Serglycin proteoglycan is not implicated in localizing exocrine pancreas enzymes to zymogen granules
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
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2009 (English)In: European Journal of Cell Biology, ISSN 0171-9335, E-ISSN 1618-1298, Vol. 88, no 8, 473-479 p.Article in journal (Refereed) Published
Abstract [en]

Storage and release of proteins from granules forms the basis of cellular functions as diverse as cell mediated cytotoxicity, neuronal communication, activation of muscle fibres, and release of hormones or digestive enzymes from endocrine and exocrine glands, such as the pancreas. Serglycin is the major intracellular proteoglycan of haematopoietic cells. Serglycin is important for localization of proteins in granules of different haematopoietic cell types. Previous reports have indicated a role for serglycin in granule formation and localization of zymogens in granules of the exocrine pancreas in rat. We here present data showing that serglycin is not present at the protein level in human or murine pancreas. Furthermore, the amount and localization of three exocrine pancreas zymogens (amylase, trypsinogen, and carboxypeptidase A) is not affected by the absence of serglycin in a serglycin knock-out mouse model.

Place, publisher, year, edition, pages
2009. Vol. 88, no 8, 473-479 p.
Keyword [en]
Human, Mouse, Granule formation, Secretory granules, Glycosaminoglycan, Proteoglycan, Serglycin, Sorting, Pancreas
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-119627DOI: 10.1016/j.ejcb.2009.03.002ISI: 000268056900005PubMedID: 19446360OAI: oai:DiVA.org:uu-119627DiVA: diva2:300562
Available from: 2010-02-26 Created: 2010-02-26 Last updated: 2011-03-04Bibliographically approved

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