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Novel insights into the biological function of mast cell carboxypeptidase A
Swedish University of Agricultural Sciences, Dept of Molecular Biology, Uppsala, Sweden.ORCID iD: 0000-0002-7180-8758
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2009 (English)In: Trends in immunology, ISSN 1471-4906, E-ISSN 1471-4981, Vol. 30, no 8, 401-408 p.Article, review/survey (Refereed) Published
Abstract [en]

When mast cells are activated they can respond by releasing their secretory granule compounds, including mast cell-specific proteases of chymase, tryptase and carboxypeptidase A (MC-CPA) type. MC-CPA is a dominant protein component of the mast cell granule and the MC-CPA gene is extremely highly expressed. Despite this, relatively little has been known of its biological function. However, the recent generation of mouse strains lacking MC-CPA has opened up new possibilities for investigations related to this protease. This recent development has revealed a role for MC-CPA in regulating innate immunity responses, including the degradation of harmful substances such as the vasoconstrictive factor endothelin 1 and snake venom toxins. Here, we summarize the current knowledge of MC-CPA.

Place, publisher, year, edition, pages
2009. Vol. 30, no 8, 401-408 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-119630DOI: 10.1016/j.it.2009.04.008ISI: 000269381500003PubMedID: 19643669OAI: oai:DiVA.org:uu-119630DiVA: diva2:300567
Available from: 2010-02-26 Created: 2010-02-26 Last updated: 2017-12-12Bibliographically approved

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Knight, Stefan D.Henningson, Frida

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