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Serglycin proteoglycan: regulating the storage and activities of hematopoietic proteases
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2009 (English)In: Biofactors, ISSN 0951-6433, E-ISSN 1872-8081, Vol. 35, no 1, 61-68 p.Article in journal (Refereed) Published
Abstract [en]

Serglycin (SG), like all other proteoglycans, consists of a protein "core" to which sulfated and thereby negatively charged polysaccharide chains of glycosaminoglycan type are attached. The recent generation of mice lacking a functional SG gene has revealed a number of biological functions of SG. In particular, it has been shown that SG has a key role in promoting the storage and in regulating the activities of a number of proteases expressed in hematopoietic cell types, most notably various mast cell proteases. In this review, we summarize the recent development in our understanding of the biological function of SG, in particular by focusing on the novel insight provided through analysis of the SG-deficient mouse strain.

Place, publisher, year, edition, pages
2009. Vol. 35, no 1, 61-68 p.
Keyword [en]
Serglycin, proteoglycans, mast cells, proteases, hematopoietic cells
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-119647DOI: 10.1002/biof.11ISI: 000266632800010PubMedID: 19319847OAI: oai:DiVA.org:uu-119647DiVA: diva2:300588
Available from: 2010-02-26 Created: 2010-02-26 Last updated: 2017-12-12Bibliographically approved

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