Integrin α1β1 is Involved in the Differentiation into Myofibroblasts in Adult Reactive Tissues in vivo
2009 (English)In: Journal of Cellular and Molecular Medicine (Print), ISSN 1582-1838, Vol. 13, no 9b, 3449-3462 p.Article in journal (Refereed) Published
Connective tissue cell activation is of importance during reactive conditions such as solid tumor growth, wound healing and pannus formation in rheumatoid arthritis. Here we have compared connective tissue cells of mesenchymal origin in human tissues from these conditions and their normal counterparts using a panel of cell type-specific markers. In particular, we investigated variations of integrin expression among connective tissue cell phenotypes. Connective tissue cell populations were defined based on their association with the microvasculature and their expression of activation markers. The phenotype of these cells varied according to the type of pathological connective tissue examined. Our morphological data from human tissues suggested that the alpha1beta1 integrin, a collagen/laminin receptor, is involved in the differentiation of precursor cells to myofibroblasts. In order to mechanistically investigate this hypothesis we employed experimental models for carcinoma growth and wound healing utilizing alpha1 integrin deficient mice. The data confirmed that the alpha1beta1 integrin is of importance for the differentiation of mesenchymal cells to myofibroblasts but also for neovascularization and connective tissue organization and emphasizes the importance of myofibroblasts in the pathophysiology of tissue repair, inflammation and tumor growth.
Place, publisher, year, edition, pages
2009. Vol. 13, no 9b, 3449-3462 p.
Adenocarcinoma rheumatoid arthritis, Integrin connective tissue, Matrigel, Myofibroblast, Pericyte
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-119722DOI: 10.1111/j.1582-4934.2008.00638.xISI: 000274179300044PubMedID: 19397781OAI: oai:DiVA.org:uu-119722DiVA: diva2:300741