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Lowered albumin extravasation rate in heart but not in other organs in beta3-integrin-deficient mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2009 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 197, no 4, 305-311 p.Article in journal (Refereed) Published
Abstract [en]

AIM: The vascular protein permeability is dependent on the integrity of the vascular wall. The heart capillaries in male mice lacking beta3 integrins have an immature phenotype. Previously, we have demonstrated a role for alphavbeta3 integrins in control of interstitial fluid pressure (Pif) and thereby in the fluid flux during inflammation. We wanted to explore a possible role for alphavbeta3 integrins in controlling capillary protein permeability during control situation and inflammation. METHODS: We performed double-tracer and microdialysis experiments on beta3-integrin-deficient mice and wild type control mice. We also measured blood pressure and heart rate in the two mice strains. RESULTS: We found reduced albumin extravasation (during 25 min) in the heart capillaries (0.053 +/- 0.003 vs. 0.087 +/- 0.009 mL g(-1) dw, P < 0.05), and an increased cardiac mass/body weight (5.3 x 10(-3) +/- 0.3 x 10(-3) vs. 3.8 x 10(-3) +/- 0.1 x 10(-3), P < 0.01) in the beta3-integrin-deficient mice (n = 6) compared with the controls (n = 6). Heart rate and blood pressure were the same in mice with and without beta3-integrins. No difference in permeability was found in other tissues studied, or under local inflammation. CONCLUSION: These results show a function for the alphavbeta3 integrin in the regulation of protein permeability, selective for the heart capillaries.

Place, publisher, year, edition, pages
2009. Vol. 197, no 4, 305-311 p.
Keyword [en]
albumin extravasation, endothelium, inflammation, microcirculation, tissue fluid balance
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-119730DOI: 10.1111/j.1748-1716.2009.02025.xISI: 000271263400005PubMedID: 19645751OAI: oai:DiVA.org:uu-119730DiVA: diva2:300751
Available from: 2010-03-01 Created: 2010-03-01 Last updated: 2011-06-28Bibliographically approved

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