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Vascular niche of pancreatic islets
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2009 (English)In: Expert Review of Endocrinology & Metabolism, ISSN 1744-6651, Vol. 4, no 5, 481-491 p.Article in journal (Refereed) Published
Abstract [en]

Pancreatic islets are highly vascularized micro-organs. Approximately 10% of an islet consists of blood vessels. The induction and maintenance of the islet vascular system depend on VEGF secreted from β-cells. VEGF is also critical for the phenotype of the islet vasculature by induction of a vast number of fenestrae. The islet vasculature serves the role of supplying the endocrine cells with oxygen and nutrients, but may also be important for proper glucose sensing of the cells, for paracrine support of endocrine function and growth, and for drainage of metabolites and secreted islet hormones into the systemic circulation. Emerging evidence suggests an important role of islet endothelial cells to maintain β-cell function and growth by secretion of molecules such as hepatocyte growth factor, thrombospondin-1 and laminins, thereby forming a vascular niche for the endocrine cells.

Place, publisher, year, edition, pages
2009. Vol. 4, no 5, 481-491 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-119770DOI: 10.1586/eem.09.25OAI: oai:DiVA.org:uu-119770DiVA: diva2:300886
Available from: 2010-03-01 Created: 2010-03-01 Last updated: 2010-11-17Bibliographically approved

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