Motivation for sucrose in sated rats is predicted by low anxiety-like behavior
2009 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 454, no 3, 193-197 p.Article in journal (Refereed) Published
Anxiety has been implicated in obesity and in the overconsumption of highly palatable foods such as those high in fat, sugar, or both. Also, the novelty-seeking trait has been associated with failure in weight-loss programs. The aim of this study was to investigate the associations of experimental anxiety and the self-administration of sucrose and high fat pellets in non-food deprived rats across different operant schedules. Male Wistar rats were subjected to the elevated plus-maze test (EPM) of anxiety-like behavior. The rats were tested for fixed ratio 5 (FR5) and progressive ratio (PR) operant responding for 50% sucrose, 95% sucrose, and high-fat pellets. PR active lever press response for 95% sucrose, but not the other pellet types, was correlated to % time spent on open arms (P=0.019) in the EPM. On the FR5 schedule, activity (closed arm entries) was correlated to the self-administration of 50% sucrose (P=0.027) and high-fat (P=0.002). This indicates an association of novelty-induced activity and self-administration of palatable food in sated rats, as well as a specific association of PR lever press response for 95% sucrose and low anxiety-like behavior. It has been argued that such active lever press response on PR may be interpreted as craving for the reinforcer; thus, our findings indicate an inverse relationship of experimental anxiety and craving for sucrose. This connection may have implications for human situations, since anxiety and novelty-seeking have been associated with obesity and failure in weight-loss programs.
Place, publisher, year, edition, pages
Elsevier , 2009. Vol. 454, no 3, 193-197 p.
Craving; Sucrose, Dietary fat, Progressive ratio, Anxiety, Novelty-seeking
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-117599DOI: 10.1016/j.neulet.2009.03.045ISI: 000265275500005PubMedID: 19429082OAI: oai:DiVA.org:uu-117599DiVA: diva2:300944