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C-Peptide: The missing link in diabetic nephropathy?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi. (Nordquist)
2009 (English)In: The review of diabetic studies : RDS, ISSN 1614-0575, Vol. 6, no 3, 203-210 p.Article in journal (Refereed) Published
Abstract [en]

Proinsulin C-peptide has been found to exert beneficial effects in many tissues affected by diabetic microvascular complications, including the kidneys. Glomerular hyperfiltration and microalbuminuria are early markers of diabetic nephropathy. C-peptide at physiological concentrations effectively reduces diabetes-induced glomerular hyperfiltration via constriction of the afferent arteriole, dilation of the efferent arteriole, and inhibition of tubular reabsorption in experimental models of type 1 diabetes. The glomerular hypertrophy and mesangial matrix expansion seen in early diabetes can be reduced or prevented by C-peptide administration, possibly via interference with TGF-beta1 and TNFalpha signaling. Several of C-peptide's reno-protective effects have been confirmed in human studies; reduced glomerular hyperfiltration and diminished urinary albumin excretion have been documented in type 1 diabetes patients receiving replacement doses of C-peptide for periods of up to 3 months. In this review, we critically summarize the current state of knowledge regarding C-peptide's renal effects, and discuss possible mechanisms of its beneficial effects in diabetic nephropathy.

Place, publisher, year, edition, pages
2009. Vol. 6, no 3, 203-210 p.
Keyword [en]
diabetes, C-peptide, nephropathy, microalbuminuria, glomerular hypertrophy, capillary pressure
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-119865DOI: 10.1900/RDS.2009.6.203PubMedID: 20039009OAI: oai:DiVA.org:uu-119865DiVA: diva2:301080
Available from: 2010-03-02 Created: 2010-03-02 Last updated: 2011-11-07Bibliographically approved

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