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Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi. (Nordquist)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi.
2008 (English)In: Biologics, ISSN 1177-5475, Vol. 2, no 3, 441-452 p.Article in journal (Refereed) Published
Abstract [en]

C-peptide has long been thought to be an inert byproduct of insulin production, but it has become apparent, and accepted, that C-peptide has important biological properties. C-peptide displays beneficial effects in many tissues affected by diabetic complications, such as increased peripheral blood flow and protection from renal damage. However, the mechanisms mediating these effects remain unclear. C-peptide interacts with cellular membranes at unidentified sites distinctive of the insulin family of receptors, and signals to multiple targets known to play a role in diabetes and diabetic complications, such as Na(+)/K(+)-ATPase and NOS. In general, the physiological and molecular effects of C-peptide resemble insulin, but C-peptide also possesses traits separate from those of insulin. These basic studies have been confirmed in human studies, suggesting that C-peptide may lend itself to clinical applications. However, the molecular and physiological properties of C-peptide are not completely elucidated, and large clinical studies have not begun. In order to further these goals, we critically summarize the current state of knowledge regarding C-peptide's renal and vascular effects and the molecular signaling of C-peptide.

Place, publisher, year, edition, pages
2008. Vol. 2, no 3, 441-452 p.
Keyword [en]
C-peptide, insulin, diabetes mellitus, nephropathy, vascular, signaling
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-119867DOI: 10.2147/BTT.S3221PubMedID: 19707375OAI: oai:DiVA.org:uu-119867DiVA: diva2:301081
Available from: 2010-03-02 Created: 2010-03-02 Last updated: 2011-11-17Bibliographically approved

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