Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action
2008 (English)In: Biologics, ISSN 1177-5475, Vol. 2, no 3, 441-452 p.Article in journal (Refereed) Published
C-peptide has long been thought to be an inert byproduct of insulin production, but it has become apparent, and accepted, that C-peptide has important biological properties. C-peptide displays beneficial effects in many tissues affected by diabetic complications, such as increased peripheral blood flow and protection from renal damage. However, the mechanisms mediating these effects remain unclear. C-peptide interacts with cellular membranes at unidentified sites distinctive of the insulin family of receptors, and signals to multiple targets known to play a role in diabetes and diabetic complications, such as Na(+)/K(+)-ATPase and NOS. In general, the physiological and molecular effects of C-peptide resemble insulin, but C-peptide also possesses traits separate from those of insulin. These basic studies have been confirmed in human studies, suggesting that C-peptide may lend itself to clinical applications. However, the molecular and physiological properties of C-peptide are not completely elucidated, and large clinical studies have not begun. In order to further these goals, we critically summarize the current state of knowledge regarding C-peptide's renal and vascular effects and the molecular signaling of C-peptide.
Place, publisher, year, edition, pages
2008. Vol. 2, no 3, 441-452 p.
C-peptide, insulin, diabetes mellitus, nephropathy, vascular, signaling
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-119867DOI: 10.2147/BTT.S3221PubMedID: 19707375OAI: oai:DiVA.org:uu-119867DiVA: diva2:301081