Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 in Overweight and Lean Patients with Polycystic Ovary Syndrome
(English)Manuscript (preprint) (Other (popular science, discussion, etc.))
Objective: Disturbances in the fibrinolytic system are predictors of future cardiovascular events. The aim of the present study was to compare PAI-1 activity and tPA mass concentration between patients with polycystic ovary syndrome (PCOS) and control subjects.
Design: 135 PCOS patients (lean and overweight) and 81 healthy controls were recruited for the study. Blood samples for PAI-1 activity and tPA mass were collected together with anthropometric measures.
Results: Overweigth PCOS patients displayed increased tPA mass concentration in comparison with controls (p < 0.05), and this finding was consistent regardless of whether patients displayed signs of hyperandrogenism or not. When hyperandrogenism was introduced as a prerequisite for the PCOS diagnosis, overweight PCOS patients displayed increased PAI-1 activity as well, p < 0.05. Lean PCOS patients did not differ in terms of PAI-1 activity or tPA mass concentration in comparison to controls.
Conclusion: Overweight women with PCOS have impaired fibrinolysis, in particular if they also display objective biochemical markers of hyperandrogenism.
polycystic ovary syndrome, PAI-1, tPA, obesity, free androgen index (FAI)
Obstetrics, Gynecology and Reproductive Medicine
Research subject Obstetrics and Gynaecology
IdentifiersURN: urn:nbn:se:uu:diva-120221OAI: oai:DiVA.org:uu-120221DiVA: diva2:302898