Inverse association of leptin levels with renal cell carcinoma: results from a case-control study
2009 (English)In: Hormones (Athens, Greece), ISSN 1109-3099, Vol. 8, no 1, 39-46 p.Article in journal (Refereed) Published
OBJECTIVE: Leptin is primarily produced in adipose tissue and appears to play a modulatory role between metabolism and immunity. Given that obesity, a state of chronic inflammation, is an established risk factor for Renal Cell Carcinoma (RCC), we investigated the association between plasma leptin levels and RCC risk. DESIGN: This case-control study included 70 patients with newly diagnosed, histologically confirmed RCC and 280 age-, gender- and district of residence-matched controls. Anthropometric data, socio-demographic variables, medical history, lifestyle habits and dietary data were derived from a personal interview. Serum leptin and adiponectin levels were determined using standard commercial kits. Adjusted odds ratios for RCC risk were derived through multiple logistic regression analyses. RESULTS: Leptin levels were inversely associated with RCC risk (OR: 0.53, CI: 0.28- 0.99, p = 0.05), even after controlling for potential confounding factors, such as Body Mass Index (BMI), recent weight change, history of diabetes mellitus and other obesity related hormones, notably adiponectin. CONCLUSIONS: The precise mechanism linking obesity with RCC remains unclear; however, the inverse association of leptin with RCC might be attributed, at least in part, to hormonal cross-talk with complex neuron-endocrine and immune circuits. These findings, if confirmed in prospective and interventional studies, might further elucidate the underlying mechanisms.
Place, publisher, year, edition, pages
2009. Vol. 8, no 1, 39-46 p.
Adiponectin, Immunity, Inflammation, Leptin, Obesity, Renal cell carcinoma
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-120256ISI: 000263924600004PubMedID: 19278051OAI: oai:DiVA.org:uu-120256DiVA: diva2:302941