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The Dominant white mutation in the PMEL17 gene does not cause visual impairment in chickens
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Neuroscience.
2009 (English)In: Veterinary Ophthalmology, ISSN 1463-5216, E-ISSN 1463-5224, Vol. 12, no 5, 292-298 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE:

To examine whether the Dominant white mutation (causing a hypopigmented phenotype in chicken) affects the visual ability and gives rise to ocular abnormalities in chickens (Gallus gallus).

PROCEDURE:

Chickens homozygous for either the Dominant white mutation or the wild-type alleles were tested in a visual contrast behavioral test and subjected to histological and ophthalmologic examination.

RESULTS:

There were no differences between the genotypes in the visual contrast behavioral test, and there were no abnormal structures among the Dominant white chickens in the ophthalmic examination. The histological sections from the Dominant white chickens did not differ from the wild-type chicken in structure, photoreceptor density, or RPE pigmentation.

CONCLUSIONS:

The results indicate that the Dominant white mutation in PMEL17 does not seem to affect the visual ability or eye structures in chickens.

Place, publisher, year, edition, pages
2009. Vol. 12, no 5, 292-298 p.
Keyword [en]
chickens, Dominant white, ocular abnormalities, pigmentation, PMEL17, visual impairment
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-120385DOI: 10.1111/j.1463-5224.2009.00714.xISI: 000269709000003PubMedID: 19751488OAI: oai:DiVA.org:uu-120385DiVA: diva2:303240
Available from: 2010-03-11 Created: 2010-03-11 Last updated: 2017-12-12Bibliographically approved

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Hallböök, Finn

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