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Acetylcholinesterase inhibitors in myasthenia gravis: to be or not to be?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology. (neurofysiologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology. (neurofysiologi)
2009 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 39, no 6, 724-728 p.Article, review/survey (Refereed) Published
Abstract [en]

Myasthenia gravis (MG) is an autoimmune disorder usually caused by antibodies against either the acetylcholine receptor (AChR) or muscle-specific tyrosine kinase (MuSK) at the neuromuscular junction. Neuromuscular transmission failure results in muscle fatigue and weakness that can be treated symptomatically with acetylcholinesterase inhibitors (AChEIs). Long-term treatment with nonselective AChEIs may have considerable drawbacks; thus, this medication is ideally tapered when strength improves. Patients with AChR antibodies respond beneficially to treatment, whereas patients with MuSK antibodies generally do not. Recently, the selective AChEI EN101, which specifically targets the isoform of "read-through" AChE (AChE-R), has been developed and may be of importance for symptomatic relief in AChR-antibody seropositive MG. This article is a review of the mechanisms, therapeutic effects, and drawbacks, with both old and new AChEIs in MG.

Place, publisher, year, edition, pages
2009. Vol. 39, no 6, 724-728 p.
Keyword [en]
MG, acetylcholinesterase inhibitors, AChEI, neuromuscular, MuSK
National Category
Physiology
Research subject
Clinical Neurophysiology
Identifiers
URN: urn:nbn:se:uu:diva-120668DOI: 10.1002/mus.21319ISI: 000266360100001PubMedID: 19260048OAI: oai:DiVA.org:uu-120668DiVA: diva2:303804
Available from: 2010-03-15 Created: 2010-03-15 Last updated: 2014-09-01Bibliographically approved

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Rostedt Punga, AnnaStålberg, Erik

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