Estrogen receptor-α expression in nociceptive-responsive neurons in the medullary dorsal horn of the female rat
2010 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 14, no 3, 245-248 p.Article in journal (Refereed) Published
Estrogens exert a substantial influence on the transmission of nociceptive stimuli and the susceptibility to pain disorders as made evident by studies in both animals and human subjects. The estrogen receptor (ER) seems to be of crucial importance to the cellular mechanisms underlying such an influence. However, it has not been clarified whether nociceptive neurons activated by pain express ERs. In this study, a noxious injection of formalin was given into the lower lip of female rats, thereby activating nociceptive neurons in the trigeminal subnucleus caudalis as demonstrated by immunohistochemical labeling of Fos. Using a dual-label immunohistochemistry protocol ERalpha-containing cells were visualized in the same sections. In the superficial layers of the medullary dorsal horn, 12% of ERalpha-labeled cells, mainly located in lamina II, also expressed noxious-induced Fos. These findings show that nociceptive-responsive neurons in the medullary dorsal horn express ERalpha, thus providing a possible morphological basis for the hypothesis that estrogens directly regulate pain transmission at this level.
Place, publisher, year, edition, pages
Elsevier , 2010. Vol. 14, no 3, 245-248 p.
Estrogen receptor, Spinal trigeminal nucleus, Gonadal hormone, Pain, Fos
Research subject Clinical Neurophysiology
IdentifiersURN: urn:nbn:se:uu:diva-120674DOI: 10.1016/j.ejpain.2009.05.008PubMedID: 19525133OAI: oai:DiVA.org:uu-120674DiVA: diva2:303809