uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Cardiovascular diseases and hippocampal infarcts
Show others and affiliations
2011 (English)In: Hippocampus, ISSN 1050-9631, E-ISSN 1098-1063, Vol. 21, no 3, 281-287 p.Article in journal (Refereed) Published
Abstract [en]

The prevalence of hippocampal lesions such as hippocampal infarcts have not been studied in detail even though hippocampal alterations are known to be associated with various clinical conditions such as age-related degenerative disorders and epilepsy. Methods: Here we defined the hippocampal infarcts and assessed the prevalence of this lesion in large unselected population of 1,245 subjects age ranging from 1 to 99 years (mean age 79 +/- 1 S.E.M). Furthermore, we assessed the association of these lesions with various cardio- and cerebro-vascular disorders and other neurodegenerative lesions. The prevalence of hippocampal infarct in the study population of 1,245 subjects was 12%, increasing to 13% when only those with a clinically diagnosed cognitive impairment (n = 311) were analyzed. Large hemispheric brain infarcts were seen in 31% of the study subjects and these lesions were strongly associated with cardiovascular risk factors such as hypertension (43%), coronary disease (32%), myocardial infarct (22%), atrial fibrillation (20%), and heart failure (20%). In contrast, hippocampal infarcts displayed a significant association only with large hemispheric brain infarct, heart failure, and cardiovascular index as assessed postmortem. It is noteworthy that only widespread hippocampal infarcts were associated with clinical symptoms of cognitive impairment or epilepsy. The surprisingly low prevalence of 12% of hippocampal infarcts in aged population found here and the failure to detect an association between this lesion and various cerebro- cardio-vascular lesions is intriguing. Whether susceptibility to ischemia in line with susceptibility to neuronal degeneration in this region is influenced by still undetermined risk- factors need further investigation. Furthermore it should be noted that the size of the hippocampal tissue damage, i.e., small vs. large cystic infarcts is of significance regarding clinical alterations.

Place, publisher, year, edition, pages
2011. Vol. 21, no 3, 281-287 p.
Keyword [en]
Cardiovascular disease, Hippocampus, Histology, Infarct, Postmortem study
National Category
Medical Genetics
URN: urn:nbn:se:uu:diva-120763DOI: 10.1002/hipo.20747ISI: 000288033600006PubMedID: 20054813OAI: oai:DiVA.org:uu-120763DiVA: diva2:303956
Available from: 2010-03-16 Created: 2010-03-16 Last updated: 2011-03-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Alafuzoff, Irina
By organisation
Department of Immunology, Genetics and Pathology
In the same journal
Medical Genetics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 293 hits
ReferencesLink to record
Permanent link

Direct link