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Increased circulating levels of the antiangiogenic factor endostatin in early-onset but not late-onset preeclampsia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
2009 (English)In: Reproductive Sciences, ISSN 1933-7191, Vol. 16, no 10, 995-1000 p.Article in journal (Refereed) Published
Abstract [en]

Changes in circulating angiogenic factors seem to play a key role in the pathogenesis of preeclampsia and it seems as if these changes are of greater importance in the pathogenesis of early-onset than of late-onset disease. Endostatin is a potent, broad spectrum antagonist of angiogenesis whose role in preeclampsia is poorly investigated. The aim of this study was to estimate whether circulating endostatin levels are altered in preeclampsia, and whether women with early-onset (before 32 weeks of gestation; n = 16) and late-onset (after 35 weeks of gestation; n = 19) preeclampsia differ in this regard. Women with early-onset, but not of late-onset preeclampsia had higher levels of endostatin than healthy pregnant women in corresponding lengths of gestation. The results of the study support the hypothesis that there is heterogeneity between early- and late-onset preeclampsia, with a stronger association between an altered angiogenic balance and early-onset than late-onset disease.

Place, publisher, year, edition, pages
2009. Vol. 16, no 10, 995-1000 p.
Keyword [en]
Preeclampsia, endostatin, early-onset, late-onset
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-120817DOI: 10.1177/1933719109339348ISI: 000270272600008PubMedID: 19564642OAI: oai:DiVA.org:uu-120817DiVA: diva2:303993
Available from: 2010-03-16 Created: 2010-03-16 Last updated: 2010-07-02Bibliographically approved

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