uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The angiogenic growth factors HGF and VEGF in serum and plasma from neuroblastoma patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Show others and affiliations
2009 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 29, no 8, 3311-3319 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To determine whether concentrations of the angiogenic growth factors hepatocyte growth factor (HGF) and vascular endothelial growth factor A (VEGF-A) correlate with clinical and genetic markers in samples taken at diagnosis in children with neuroblastoma (NB). PATIENTS AND METHODS: Heparin plasma (P-) and serum (S-) samples of healthy controls (n=73, mean age +/- SD 3.5+/-2.1; females/males: 23/50) and patients with NB (n=62; 2.2+/-1.8; 26/36) were collected between 1988 and 1999. Clinical data included age at diagnosis, gender, stage, outcome, amplification of the oncogene MYCN, loss of heterozygosity at the short arm of chromosome 1 (1p LOH) and ploidy. RESULTS: HGF and S-VEGF-A were elevated in NB as compared to controls (38/62 patients, p<0.0001 and p<0.05, Mann-Whitney U test). HGF concentrations were higher in high-stage (stage 3-4) as compared to low-stage (stage 1-2) disease (p<0.01). P-HGF was elevated in patients with 1p LOH (p<0.01), MYCN amplification (p<0.001) and di- or tetraploidy (p<0.001). S-HGF concentration was elevated in patients MYCN-amplified tumors only. Plasma and S-HGF concentrations were higher in the deceased group (p<0.05), but not P or S-VEGF-A. CONCLUSION: This study showed that concentrations of HGF and S-VEGF-A are elevated in patients with NB. Furthermore, HGF and S-VEGF-A concentrations correlate to higher stage disease and HGF correlates to genetic markers known to indicate a poor outcome. These observations imply that HGF and VEGF-A have biological roles in NB and suggest the possibility of interference with HGF or VEGF-A signaling as a therapeutic strategy.

Place, publisher, year, edition, pages
2009. Vol. 29, no 8, 3311-3319 p.
Keyword [en]
Angiogenesis factor, hepatocyte growth factor, vascular endothelial growth factor, tumor markers
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-120837ISI: 000268846800061PubMedID: 19661350OAI: oai:DiVA.org:uu-120837DiVA: diva2:304002
Available from: 2010-03-16 Created: 2010-03-16 Last updated: 2010-07-12Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Surgical SciencesClinical ChemistryDepartment of Genetics and PathologyDepartment of Women's and Children's HealthDepartment of Medical Biochemistry and Microbiology
In the same journal
Anticancer Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 258 hits
ReferencesLink to record
Permanent link

Direct link