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Gene expression analysis of human endometrial endothelial cells exposed to Bisphenol A
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
2009 (English)In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 28, no 1, 18-25 p.Article in journal (Refereed) Published
Abstract [en]

Bisphenol A (BPA) can affect reproductive tissues in several species. Recently, treatment of human endometrial endothelial cells (HEECs) with 100 microM BPA decreased their proliferation and viability. In the present study, 50 microM BPA decreased HEEC proliferation, and microarray analyses of five HEEC cultures revealed that BPA affected biological processes associated with proliferation. Expression of three of the most differentially expressed genes identified in the gene array analysis, SPBC25, SGOL2 and CDCA8, was verified by real-time qRT-PCR in five HEEC cultures obtained from women in the proliferative phase and in five cultures obtained from women in the secretory phase of the menstrual cycle after treatment with BPA. This study supports our previous findings of decreased cell proliferation and increased cell death in response to BPA, and may offer important clues to the mechanisms of action of BPA. Furthermore, the study implies a possible impact of BPA on female fertility functions.

Place, publisher, year, edition, pages
2009. Vol. 28, no 1, 18-25 p.
Keyword [en]
Bisphenol A, Endocrine disruptor, Endometrium, Endothelial cells, In vitro, Human endometrial endothelial cells, Microarray, Reproductive tissue
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-121055DOI: 10.1016/j.reprotox.2009.03.006ISI: 000267198600003PubMedID: 19490990OAI: oai:DiVA.org:uu-121055DiVA: diva2:304467
Available from: 2010-03-18 Created: 2010-03-18 Last updated: 2017-12-12Bibliographically approved

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