Evidence of increased oxidative stress and a change in the plasminogen activator inhibitor (PAI)-1 to PAI-2 ratio in early-onset but not late-onset preeclampsia
2009 (English)In: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 201, no 6, 597.e1- p.Article in journal (Refereed) Published
OBJECTIVE: The aims of this study were to measure the degree of oxidative stress and alterations in plasminogen activator inhibitor (PAI) type 1 and PAI-2 ratio in women with early-onset and late-onset preeclampsia. STUDY DESIGN: A case-control study was conducted in women with early-onset (24-32 weeks' gestation; n=18) and late-onset (35-42 weeks' gestation; n=20) preeclampsia and in control pregnant women at corresponding gestational weeks. Placenta, urine, and serum samples were collected. RESULTS: In early-onset preeclampsia, the median placental concentration of 8-iso-prostaglandin (PG)-F2alpha was higher and the PAI-1 to PAI-2 ratio higher than in early controls. These values did not differ between women with late-onset preeclampsia and their corresponding controls. Serum concentrations of 8-iso-PGF2alpha and vitamins C and E did not differ between cases and controls. CONCLUSION: Early-onset but not late-onset preeclampsia is associated with increased placental oxidative stress and increased PAI-1 to PAI-2 ratio.
Place, publisher, year, edition, pages
2009. Vol. 201, no 6, 597.e1- p.
isoprostanes, oxidative stress, plasminogen activator inhibitor-1 to plasminogen activator inhibitor-2 ratio, preeclampsia
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-121357DOI: 10.1016/j.ajog.2009.06.024ISI: 000272337600026PubMedID: 19683696OAI: oai:DiVA.org:uu-121357DiVA: diva2:305009