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Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Lobell / Kämpe)
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1998 (English)In: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 187, no 9, 1543-1548 p.Article in journal (Refereed) Published
Abstract [en]

We explore here if vaccination with DNA encoding an autoantigenic peptide can suppress autoimmune disease. For this purpose we used experimental autoimmune encephalomyelitis (EAE), which is an autoaggressive disease in the central nervous system and an animal model for multiple sclerosis. Lewis rats were vaccinated with DNA encoding an encephalitogenic T cell epitope, guinea pig myelin basic protein peptide 68-85 (MBP68-85), before induction of EAE with MBP68-85 in complete Freund's adjuvant. Compared to vaccination with a control DNA construct, the vaccination suppressed clinical and histopathological signs of EAE, and reduced the interferon gamma production after challenge with MBP68-85. Targeting of the gene product to Fc of IgG was essential for this effect. There were no signs of a Th2 cytokine bias. Our data suggest that DNA vaccines encoding autoantigenic peptides may be useful tools in controlling autoimmune disease.

Place, publisher, year, edition, pages
1998. Vol. 187, no 9, 1543-1548 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-121542DOI: 10.1084/jem.187.9.1543PubMedID: 9565646OAI: oai:DiVA.org:uu-121542DiVA: diva2:305673
Available from: 2010-03-24 Created: 2010-03-24 Last updated: 2010-06-04Bibliographically approved

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