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Expression of T cell immunoglobulin- and mucin-domain-containing molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune systems
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Lobell / Kämpe)
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2005 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 164, no 1, 93-104 p.Article in journal (Refereed) Published
Abstract [en]

Expression of T cell immunoglobulin- and mucin-domain-containing molecules (TIMs) can be used as T helper (Th) differentiation markers in the human and mouse. We examined the expression of TIM-1 and -3 mRNAs in rat MBP(63-88)-induced experimental autoimmune encephalomyelitis (EAE). TIM-3 expression was upregulated in the spinal cord during EAE and following antigen restimulation of the encephalitogenic TCRBV8S2+ population. Interestingly, TIM-3 expression was also detected by in situ hybridization in resident cells of the nervous system. TIM-1 was expressed in B cells but not in resident CNS cells and TIM-1 mRNA levels in spinal cord were unchanged throughout the course of EAE. These results support the notion that TIM-3 can also be used as a Th1 differentiation marker in the rat. However, expression of TIM-1 and -3 is not restricted solely to T cells and the presence of TIM-3 in resident CNS cells may indicate a role for this molecule in the interaction between the nervous and immune systems.

Place, publisher, year, edition, pages
2005. Vol. 164, no 1, 93-104 p.
Keyword [en]
Th1/Th2 cells, Cell surface molecules, Experimental autoimmune encephalomyelitis, Real-time quantitative RT-PCR, TCRBV8S2+ T cells
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-121543DOI: 10.1016/j.jneuroim.2005.04.004PubMedID: 15913792OAI: oai:DiVA.org:uu-121543DiVA: diva2:305679
Available from: 2010-03-24 Created: 2010-03-24 Last updated: 2010-05-26Bibliographically approved

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