Iridium-N,P-ligand-catalyzed enantioselective hydrogenation of diphenylvinylphosphine oxides and vinylphosphonates
2009 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 131, no 23, 8285-8289 p.Article in journal (Refereed) Published
Diphenylvinylphosphine oxides and di- and trisubstituted vinylphosphonates have been employed as substrates in iridium-catalyzed asymmetric hydrogenations. Complete conversions and excellent enantioselectivities (up to and above 99% ee) were observed for a range of substrates with both aromatic and aliphatic groups at the prochiral carbon. We have also hydrogenated electron-deficient carboxyethylvinylphosphonates with excellent stereoselectivity (up to and above 99% ee). The hydrogenated products of both classes of substrates are synthetically useful intermediates.
Place, publisher, year, edition, pages
2009. Vol. 131, no 23, 8285-8289 p.
IdentifiersURN: urn:nbn:se:uu:diva-121865DOI: 10.1021/ja901437tISI: 000267623100057PubMedID: 19462955OAI: oai:DiVA.org:uu-121865DiVA: diva2:306891