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Single-Shot Diffractive Imaging with a Table-Top Femtosecond Soft X-Ray Laser-Harmonics Source
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2009 (English)In: Physical Review Letters, ISSN 0031-9007, Vol. 103, no 2, 028104- p.Article in journal (Refereed) Published
Abstract [en]

Coherent x-ray diffractive imaging is a powerful method for studies on   nonperiodic structures on the nanoscale. Access to femtosecond dynamics   in major physical, chemical, and biological processes requires   single-shot diffraction data. Up to now, this has been limited to   intense coherent pulses from a free electron laser. Here we show that   laser-driven ultrashort x-ray sources offer a comparatively inexpensive  alternative. We present measurements of single-shot diffraction patterns from isolated nano-objects with a single 20 fs pulse from a   table-top high-harmonic x-ray laser. Images were reconstructed with a   resolution of 119 nm from the single shot and 62 nm from multiple shots.

Place, publisher, year, edition, pages
2009. Vol. 103, no 2, 028104- p.
National Category
Physical Sciences
URN: urn:nbn:se:uu:diva-121910DOI: 10.1103/PhysRevLett.103.028104ISI: 000267887800065OAI: oai:DiVA.org:uu-121910DiVA: diva2:306924
Available from: 2010-03-31 Created: 2010-03-31 Last updated: 2010-07-19Bibliographically approved
In thesis
1. Ultrafast Coherent X-ray Diffractive Nanoimaging
Open this publication in new window or tab >>Ultrafast Coherent X-ray Diffractive Nanoimaging
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

X-ray lasers are creating unprecedented research opportunities in physics,chemistry and biology. The peak brightness of these lasers exceeds presentsynchrotrons by 1010, the coherence degeneracy parameters exceedsynchrotrons by 109, and the time resolution is 105 times better. In theduration of a single flash, the beam focused to a micron-sized spot has the samepower density as all the sunlight hitting the Earth, focused to a millimetresquare. Ultrafast coherent X-ray diffractive imaging (CXDI) with X-ray lasers exploitsthese unique properties of X-ray lasers to obtain high-resolution structures fornon-crystalline biological (and other) objects. In such an experiment, thesample is quickly vaporised, but not before sufficient scattered light can berecorded. The continuous diffraction pattern can then be phased and thestructure of a more or less undamaged sample recovered% (speed of light vs. speed of a shock wave).This thesis presents results from the first ultrafast X-ray diffractive imagingexperiments with linear accelerator-driven free-electron lasers and fromoptically-driven table-top X-ray lasers. It also explores the possibility ofinvestigating phase transitions in crystals by X-ray lasers. An important problem with ultrafast CXDI of small samples such as single proteinmolecules is that the signal from a single measurement will be small, requiringsignal enhancement by averaging over multiple equivalent samples. We present anumerical investigation of the problems, including the case where samplemolecules are not exactly identical, and propose tentative solutions. A new software package (Hawk) has been developed for data processing and imagereconstruction. Hawk is the first publicly available software package in thisarea, and it is released as an open source software with the aspiration offostering the development of this field.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2010. 49 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 731
XFEL, Phasing, Image Reconstruction, Single Particle Imaging, Ultrafast Diffraction, X-ray diffraction, Coherent Diffractive Imaging, CXDI
urn:nbn:se:uu:diva-122002 (URN)978-91-554-7776-9 (ISBN)
Public defence
2010-05-14, B41, BMC, Husargatan 3, Uppsala, 13:15 (English)
Available from: 2010-04-22 Created: 2010-04-05 Last updated: 2010-05-11Bibliographically approved

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Maia, F. R. N. C.
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