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Glucose generates coincident insulin and somatostatin pulses and anti-synchronous glucagon pulses from human pancreatic islets
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. (Erik Gylfe)
Lunds universitet.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. (Erik Gylfe)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. (Erik Gylfe)
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2009 (English)In: Endocrinology, ISSN 0013-7227, E-ISSN 1945-7170, Vol. 150, no 12, 5334-5340 p.Article in journal (Refereed) Published
Abstract [en]

The kinetics of insulin, glucagon and somatostatin release was studied   in human pancreatic islets. Batches of 10-15 islets were perifused and   the hormones measured with RIA in 30-sec fractions. Increase of glucose   from 3 to 20 mM resulted in a brief pulse of glucagon coinciding with   suppression of basal insulin and somatostatin release. There was a   subsequent drop of glucagon release concomitant with the appearance of   a pronounced pulse of insulin and a slightly delayed pulse of   somatostatin. Continued exposure to 20 mM glucose generated pulsatile   release of the three hormones with 7- to 8-min periods accounting for   60-70% of the secreted amounts. Glucose caused pronounced stimulation   of average insulin and somatostatin release. However, the nadirs   between the glucagon pulses were lower than the secretion at 3 mM   glucose, resulting in 18% suppression of average release. The   repetitive glucagon pulses were antisynchronous to coincident pulses of   insulin and somatostatin. The resulting greater than 20-fold variations   of the insulin to glucagon ratio might be essential for   minute-to-minute regulation of the hepatic glucose production.

Place, publisher, year, edition, pages
2009. Vol. 150, no 12, 5334-5340 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-122563DOI: 10.1210/en.2009-0600ISI: 000272042300018OAI: oai:DiVA.org:uu-122563DiVA: diva2:310550
Available from: 2010-04-14 Created: 2010-04-14 Last updated: 2017-12-12Bibliographically approved

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