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Regulatory factors of basal F2-isoprostane formation: population, age, gender and smoking habits in humans
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Oxidative Stress and Inflammation.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Oxidative Stress and Inflammation.
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2009 (English)In: Free radical research, ISSN 1071-5762, E-ISSN 1029-2470, Vol. 43, no 1, 85-91 p.Article in journal (Refereed) Published
Abstract [en]

Oxidative stress is assumed to be the key underlying factor in the pathogenesis of many common diseases. This study describes the basal levels of 8-iso-PGF(2alpha ), a major F(2)-isoprostane and an in vivo oxidative stress biomarker in healthy subjects from three countries, namely Italy, Poland and Sweden, in relation to their smoking habits, age and gender. It studied urinary 8-iso-PGF(2alpha ) in 588 subjects from Sweden (n=220), Italy (n=203) and Poland (n=165). Polish subjects had the highest levels of F(2)-isoprostanes followed by the Swedish and Italians when adjusted for smoking, age, sex and creatinine and the inter-country differences were statistically significant. Smokers had significantly higher levels of 8-iso-PGF(2alpha ) compared to non-smokers in all countries and there was a moderate decrease with age. Women had only slightly lower 8-iso-PGF(2alpha ) than men. There is a difference in F(2)-isoprostane levels in vivo between countries. Smoking, age and gender affect isoprostane formation and should be taken into consideration in clinical studies of oxidative stress.

Place, publisher, year, edition, pages
Informa Healthcare , 2009. Vol. 43, no 1, 85-91 p.
Keyword [en]
Isoprostanes, oxidative stress, variation, population, age, gender, demography, humans
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-122592DOI: 10.1080/10715760802610851ISI: 000264509500009PubMedID: 19085196OAI: oai:DiVA.org:uu-122592DiVA: diva2:310668
Available from: 2010-04-15 Created: 2010-04-15 Last updated: 2017-12-12Bibliographically approved

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Basu, SamarHelmersson, Johanna

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