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Labelling of polysaccharides using [11C]cyanogen bromide: In vivo and in vitro evaluation of 11C-hyaluronan uptake kinetics
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Reumatologi)
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1995 (English)In: Nuclear Medicine and Biology, ISSN 0969-8051, E-ISSN 1872-9614, Vol. 22, no 2, p. 251-256Article in journal (Refereed) Published
Abstract [en]

A method for the 11C-labelling of polysaccharides in high specific radioactivity is described. Dextran and hyaluronan were treated with [11C]cyanogen bromide in aqueous solution at pH 11.5 to give 30-47% radiochemical yields with higher than 98% radiochemical purity in synthesis times of 24-26 min counted from the end of bombardment. Specific radioactivities at the end of synthesis ranged from 0.12 to 3.1 Ci/mumol. The biodistribution kinetics of [11C]hyaluronan injected intravenously was studied in rats by means of positron emission tomography, showing a rapid and displaceable uptake in liver. Uptake and displacement of [11C]hyaluronan was also demonstrated in cultured rat liver endothelial cells.

Place, publisher, year, edition, pages
1995. Vol. 22, no 2, p. 251-256
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-122693DOI: 10.1016/0969-8051(94)00091-WPubMedID: 7539321OAI: oai:DiVA.org:uu-122693DiVA, id: diva2:310816
Available from: 2010-04-16 Created: 2010-04-16 Last updated: 2017-12-12Bibliographically approved

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