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The sensitivity of hyaluronan analysis of pleural fluid from patients with malignant mesothelioma and a comparison of different methods
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Reumatologi)
1994 (English)In: Cancer, ISSN 0008-543X, E-ISSN 1097-0142, Vol. 73, no 5, 1406-1410 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Hyaluronan may be used as a marker for malignant mesothelioma, thus indicating its mesodermal origin. METHODS: The sensitivity as a diagnostic test of three different methods for hyaluronan analyses of pleural fluid was examined in patients with biopsy-verified malignant pleural mesothelioma. RESULTS: A quantitative high-performance liquid-chromatography (HPLC) method was performed on fluids from 43 patients. Using a cutoff level of 100 mg/l, higher levels were noted in 30 (70%) patients, with a median value of 220 mg/l (mean, 560 mg/l; range, 20-6600 mg/l). An identical median value (220 mg/l) was obtained with a radioassay method when simultaneously performed on paired samples from 21 patients (correlation coefficient, 0.91). A qualitative precipitation test using 0.5% cetylpyridinium chloride combined with a quantitative viscosimetric method was significantly less sensitive (P < 0.01). CONCLUSION: Hyaluronan analyses is beneficial in distinguishing malignant mesothelioma if methods such as the evaluated HPLC or radioassay with a sensitivity of 70% toward mesothelioma are used and other known causes of elevated content are considered.

Place, publisher, year, edition, pages
1994. Vol. 73, no 5, 1406-1410 p.
Keyword [en]
medical oncology, mesothelioma, pleural fluid, hyaluronan, sensitivity
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-122710DOI: 10.1002/1097-0142(19940301)73:5<1406::AID-CNCR2820730515>3.0.CO;2-IPubMedID: 8111707OAI: oai:DiVA.org:uu-122710DiVA: diva2:310830
Available from: 2010-04-16 Created: 2010-04-16 Last updated: 2010-07-16Bibliographically approved

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