Post-prandial glucose levels following three methods of insulin bolusing: A study in adolescent girls and in comparison with girls without diabetes
2009 (English)In: Practical diabetes international, ISSN 1357-8170, Vol. 26, no 3, 110-115 p.Article in journal (Refereed) Published
The aims of this study were to assess whether one method of insulin bolusing wassuperior to two others in managing two pasta meals, and to compare the glucose levelswith those of females without diabetes.Fifteen continuous subcutaneous insulin infusion (CSII)-treated adolescent femalesand 10 adolescent females without diabetes consumed two pasta meals with different fatcontents. The plasma glucose (p-glucose) values were followed using capillarymeasurement and continuous glucose monitoring (CGMS) until three hours after themeal. The CSII-treated females received the same insulin dose at every occasion as:(1) normal bolus; (2) dual-wave bolus – 60% of the dose as normal bolus and 40% overone hour; and (3) square-wave bolus – a prolonged dose over one hour.No differences were found in p-glucose peak or AUC between the bolus methodsafter either of the meals. There was a difference in p-glucose increase at one time pointafter the less fat meal; after 60 minutes the increase was greater with a square-wavebolus (Friedman’s test p<0.02). Forty-eight percent of the measurements among thediabetes adolescents showed post-prandial p-glucose levels ≤10mmol/L. Femaleswithout diabetes had earlier and lower p-glucose peak and smaller AUC.It was concluded that there were no overall differences in p-glucose excursionsbetween different methods of bolusing for these adolescent females after these meals. Asquare-wave bolus may be less favourable with a less fatty pasta meal, giving a higherp-glucose increase. It was possible to achieve normoglycaemic post-prandial p-glucoselevels among adolescents with diabetes.
Place, publisher, year, edition, pages
2009. Vol. 26, no 3, 110-115 p.
type 1 diabetes mellitus, adolescents, insulin infusion systems, post-prandial glucose, bolus insulin
Nursing Endocrinology and Diabetes
Research subject Caring Sciences
IdentifiersURN: urn:nbn:se:uu:diva-122723DOI: 10.1002/pdi.1350OAI: oai:DiVA.org:uu-122723DiVA: diva2:310875