Is usage of hypnotics associated with mortality?
2009 (English)In: Sleep Medicine, ISSN 1389-9457, E-ISSN 1878-5506, Vol. 10, no 3, 279-286 p.Article in journal (Refereed) Published
Objective: To investigate the influence of hypnotic usage on all-cause and cause-specific mortality in a middle-aged population. Methods: A cohort of 1750 men and 1773 women aged 30-65 years who responded to a postal questionnaire in 1983. The questionnaire included questions about hypnotic usage, sleep duration, sleep complaints, medical conditions, depression, demographic and life style variables. Mortality data for the period 1983-2003 were collected. Results: Regular hypnotic usage wits reported by 1.7% of men and 2.2% of women, and was associated with short sleep, sleeping difficulties, several health problems and depression. During the 20-year follow-up period 379 men (21.5%) and 278 women (15.5%) died. After adjustment for potential risk factors in multivariate analyses regular hypnotic usage was associated with significantly increased risk of all-cause mortality in men (Hazard ratios [HR], 4.54; 95% confidence interval [CI], 2.47-8.37) and in women 2.03 (95% CI 1.07-3.86). With regard to cause-specific mortality, regular hypnotic usage in men was a risk factor for coronary artery disease death, cancer death, suicide and death from "all remaining causes." In women it was a risk factor for suicide. Conclusions: Our results show an increased risk of all-cause mortality and cause-specific mortality in regular users of hypnotics.
Place, publisher, year, edition, pages
2009. Vol. 10, no 3, 279-286 p.
Mortality, Hypnotics, General population, Longitudinal
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-122815DOI: 10.1016/j.sleep.2008.12.004ISI: 000266225000003PubMedID: 19269892OAI: oai:DiVA.org:uu-122815DiVA: diva2:311102