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Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis
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2010 (English)In: American journal of medical genetics. Part B, Neuropsychiatric genetics, ISSN 1552-4841, Vol. 153B, no 1, p. 235-242Article in journal (Refereed) Published
Abstract [en]

Conflicting results have been reported as to whether genetic variations (Val66Met and C270T) of the brain-derived neurotrophic factor gene (BDNF) confer susceptibility to Alzheimer's disease (AD). We genotyped these polymorphisms in a Japanese sample of 657 patients with AD and 525 controls, and obtained weak evidence of association for Val66Met (P = 0.063), but not for C270T. After stratification by sex, we found a significant allelic association between Val66Met and AD in women (P = 0.017), but not in men. To confirm these observations, we collected genotyping data for each sex from 16 research centers worldwide (4,711 patients and 4,537 controls in total). The meta-analysis revealed that there was a clear sex difference in the allelic association; the Met66 allele confers susceptibility to AD in women (odds ratio = 1.14, 95% CI 1.05-1.24, P = 0.002), but not in men. Our results provide evidence that the Met66 allele of BDNF has a sexually dimorphic effect on susceptibility to AD.

Place, publisher, year, edition, pages
2010. Vol. 153B, no 1, p. 235-242
Keyword [en]
Alzheimer's disease (AD), brain-derived neurotrophic factor (BDNF), meta-analysis, polymorphism, sex difference
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-122991DOI: 10.1002/ajmg.b.30986ISI: 000273440500027PubMedID: 19504537OAI: oai:DiVA.org:uu-122991DiVA, id: diva2:311576
Available from: 2010-04-22 Created: 2010-04-22 Last updated: 2010-12-20Bibliographically approved

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