Increased Fecal Levels of Chromogranin A, Chromogranin B and Secretoneurine in Collagenous Colitis: Fecal chromogranin A and secretoneurine in collagenous colitis and IBD
(English)Manuscript (preprint) (Other academic)
Interactions between the enteric nervous system and the immune system are suggested to play an important role in the patophysiology of inflammatory bowel disease (IBD). Aim: To determine if chromogranin A (CgA), chromogranin B (CgB) and secretoneurin (SN) are detectable in feces from patients with collagenous colitis (CC) and to compare the levels with patients with ulcerative colitis (UC) and Crohn´s disease (CD) and healthy control subjects (HC). Another aim is to examine if there is any change in fecal CgA (F-CgA), fecal CgB (F-CgB) and fecal SN (F-SN) during treatment in the same patients. Methods: Patients with active CC (n=12) were studied before and after 3, 7, 28 and 56 days of treatment. Patients with IBD (UC; n=21, CD; n=11)) were studied before and after 28 and 56 days of treatment. Clinical symptoms and stool frequency were recorded and fecal samples were collected at each occasion. F-CgA, F-CgB and F-SN were measured by RIA. Results: On day 56 eleven patients with CC, 21 with UC and 10 CD patients fulfilled the predefined remission criterion. On inclusion CC patients had higher levels of F-CgA, F-CgB and F-SN compared to patients with IBD and HC. In CC patients F-SN levels were decreased to the levels found in HC, but the values was still markedly higher than those found in patients with IBD. No change was found in F-CgA in any of the studied groups. In UC patients with a complete response to treatment, there was a significant decrease in F-CgB, but the values were within the 5th -95th percentile of the values found in HC. The F-CgB level in CC, UC patients with a non-complete response and in CD patients was unchanged. Conclusion: The markedly high levels of F-CgA, F-CgB and F-SN found in collagenous colitis indicate a role for the intestinal neuro-endocrine system in the pathogenesis of this disease.
collagenous colitis, inflammatory bowel disease, chromogranin A, chromogranin B, secretoneurin, fecal samples
Gastroenterology and Hepatology
Research subject Medicine
IdentifiersURN: urn:nbn:se:uu:diva-123041OAI: oai:DiVA.org:uu-123041DiVA: diva2:311709