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Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
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2010 (English)In: Cellular Signalling, ISSN 0898-6568, E-ISSN 1873-3913, Vol. 22, no 6, 955-960 p.Article in journal (Refereed) Published
Abstract [en]

Extracellular regulated kinase (Erk) 5 is a member of the mitogen activated protein (MAP) kinase family that has been implicated in both cell proliferation and survival. In the present study, we found that stimulation with platelet-derived growth factor (PDGF)-BB leads to a transient activation of Erk5, which was shown to be dependent on recruitment of both Src kinases and the tyrosine phosphatase Shp2 to the activated PDGF receptor beta (PDGFRbeta). We could also demonstrate that Shp2 docking to the receptor is critical for Src kinase activation, suggesting that Shp2 may contribute to Erk5 activation through its involvement in Src kinase activation. Under control conditions, PDGF-BB promoted a sustained Akt phosphorylation. However, reduction of the expression of Erk5 by siRNA resulted in only a transient Akt phosphorylation, and an inability of PDGF-BB to suppress caspase 3 activation and inhibit apoptotic nuclear morphological changes such as condensed or fragmented chromatin under serum-free conditions.

Place, publisher, year, edition, pages
Elsevier Inc. , 2010. Vol. 22, no 6, 955-960 p.
Keyword [en]
PDGF, Erk5, Akt, Caspase, Apoptosis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-123125DOI: 10.1016/j.cellsig.2010.01.020ISI: 000277091100009PubMedID: 20138986OAI: oai:DiVA.org:uu-123125DiVA: diva2:312440
Available from: 2010-04-23 Created: 2010-04-23 Last updated: 2017-12-12Bibliographically approved

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