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Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Abeta in plasma of patients with Alzheimer's disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
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2011 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 32, no 8, 1379-1387 p.Article in journal (Refereed) Published
Abstract [en]

In the present work, we investigated the level of IgM autoantibodies directed against different Abeta epitopes as potential diagnostic biomarker for Alzheimer's disease (AD). Anti-Abeta autoantibody levels were measured in 75 plasma samples from patients with AD, individuals with mild cognitive impairment (MCI), and healthy age- and sex-matched controls (HC). To validate the presence of anti-Abeta IgMs, pooled plasma samples were subjected to gel-filtration analysis. The mean level of pGluAbeta-IgM (N-terminal truncated starting at position three with pyroglutamate) was significantly decreased in AD patients as compared to HC. In the group of MCI patients there was a significant positive correlation between pGluAbeta-IgM and cognitive decline analyzed by MMSE (rho=0.58, d.f.=13, p=0.022). These observations indicate that the level of IgM autoantibodies against pGluAbeta is a promising plasma biomarker for AD and correlates with the cognitive status of individuals at risk to develop AD.

Place, publisher, year, edition, pages
2011. Vol. 32, no 8, 1379-1387 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-123189DOI: 10.1016/j.neurobiolaging.2009.08.011PubMedID: 19781815OAI: oai:DiVA.org:uu-123189DiVA: diva2:312893
Available from: 2010-04-26 Created: 2010-04-26 Last updated: 2017-12-12Bibliographically approved

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