uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Candidate gene association study for noise-induced hearing loss in two independent noise-exposed populations
Show others and affiliations
2009 (English)In: Annals of Human Genetics, ISSN 0003-4800, E-ISSN 1469-1809, Vol. 73, no 2, 215-224 p.Article in journal (Refereed) Published
Abstract [en]

Millions of people are daily exposed to high levels of noise. Consequently, noise-induced hearing loss (NIHL) is one of the most important occupational health hazards worldwide. In this study, we performed an association study for NIHL based on a candidate gene approach. 644 Single Nucleotide Polymorphisms (SNPs) in 53 candidate genes were analyzed in two independent NIHL sample sets, a Swedish set and part of a Polish set. Eight SNPs with promising results were selected and analysed in the remaining part of the Polish samples. One SNP in PCDH15 (rs7095441), resulted in significant associations in both sample sets while two SNPs in MYH14 (rs667907 and rs588035), resulted in significant associations in the Polish sample set and significant interactions with noise exposure level in the Swedish sample set. Calculation of odds ratios revealed a significant association of rs588035 with NIHL in the Swedish high noise exposure level group. Our studies suggest that PCDH15 and MYH14 may be NIHL susceptibility genes, but further replication in independent sample sets is mandatory.

Place, publisher, year, edition, pages
2009. Vol. 73, no 2, 215-224 p.
Keyword [en]
Noise-induced hearing loss, candidate gene, association study, SNP
National Category
Medical Genetics
URN: urn:nbn:se:uu:diva-123232DOI: 10.1111/j.1469-1809.2008.00499.xISI: 000263448700010PubMedID: 19183343OAI: oai:DiVA.org:uu-123232DiVA: diva2:313600
Available from: 2010-04-26 Created: 2010-04-26 Last updated: 2010-09-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Bondeson, Marie-Louise
By organisation
Department of Genetics and Pathology
In the same journal
Annals of Human Genetics
Medical Genetics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 231 hits
ReferencesLink to record
Permanent link

Direct link