Endothelial function in patients with polycystic ovary syndrome: a long-term follow-up study
2010 (English)In: Fertility and Sterility, ISSN 0015-0282, Vol. 94, no 7, 2654-2658 p.Article in journal (Refereed) Published
Objective: To investigate pulse wave reflection and endothelial-dependent vasodilatation (EDV) in PCOS patients and age-matched healthy controls. Design: Long-term follow-up study. Setting: Department of Women’s and Children’s Health, Uppsala University, Sweden. Patient(s): Sixty-seven PCOS patients with a mean age of 43.3 years at the follow-up investigation and 66 age-matched controls. Intervention: Aplanation tonometry before and after b-2 receptor agonist (terbutaline) challenge. Main outcome measure(s): Baseline augmentation index (AI) aorta, baseline AI-radial, and change in AI-radial following terbutaline administration as a measure of EDV. Result(s): There was no difference in baseline AI-aorta between PCOS patients and control subjects. Change in AI-radial following terbutaline administration was less pronounced in PCOS patients in comparison to control subjects. This difference remained when adjusted for use of combined oral contraceptives/hormone replacement therapy and postmenopausal status but not after adjustment for BMI. Conclusion(s): Middle-aged PCOS patients display signs of endothelial dysfunction in comparison to age-matched controls, but this is largely due to the increased prevalence of independent risk factors for cardiovascular disease found in this group.
Place, publisher, year, edition, pages
2010. Vol. 94, no 7, 2654-2658 p.
polycystic ovary syndrome, endothelial function, endothelial-dependent vasodilation, long-term, follow-up
Medical and Health Sciences
Research subject Obstetrics and Gynaecology
IdentifiersURN: urn:nbn:se:uu:diva-123241DOI: 10.1016/j.fertnstert.2010.02.048ISI: 000284573700034PubMedID: 20378107OAI: oai:DiVA.org:uu-123241DiVA: diva2:313606