uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation
Show others and affiliations
2011 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 32, no 8, 1388-1399 p.Article in journal (Refereed) Published
Abstract [en]

Six young related pre-symptomatic carriers of a His163Tyr mutation in the presenilin 1 gene who will develop early onset familial Alzheimer's disease (eoFAD), and a control group of 23 non-carriers underwent (18)F-fluorodeoxyglucose positron emission tomography (FDG PET). The mutation carriers were followed-up after 2 years. Multivariate analysis showed clear separation of carriers from non-carriers on both occasions, with the right thalamus being the region contributing most to group differentiation. Statistical parametric mapping (SPM) revealed in the carriers non-significantly lower thalamic cerebral glucose metabolism (CMRglc) at baseline and significantly decreased CMRglc in the right thalamus at follow-up. One mutation carrier was followed-up with FDG PET 10 years after baseline and showed reductions in cognition and CMRglc in the posterior cingulate and the frontal cortex. This subject was diagnosed with AD 1 year later and assessed with an additional FDG as well as an (11)C-PIB PET scan 12 years after baseline. Global cortical CMRglc and cognition were distinctly decreased. PIB binding was comparable with sporadic AD patterns but showing slightly higher striatal levels.

Place, publisher, year, edition, pages
2011. Vol. 32, no 8, 1388-1399 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-123413DOI: 10.1016/j.neurobiolaging.2009.08.016ISI: 000293028500004PubMedID: 19796846OAI: oai:DiVA.org:uu-123413DiVA: diva2:313918
Available from: 2010-04-27 Created: 2010-04-27 Last updated: 2015-07-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wall, AndersLångström, BengtLannfelt, Lars
By organisation
Section of Nuclear Medicine and PETDepartment of Biochemistry and Organic ChemistryGeriatrics
In the same journal
Neurobiology of Aging
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 222 hits
ReferencesLink to record
Permanent link

Direct link