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Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease
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2010 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 141, no 1, 178-190 p.Article in journal (Refereed) Published
Abstract [en]

Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and their ability to phenocopy genetic deficiency or silencing of PlGF in cancer and ocular disease but also show that not all anti-PlGF antibodies are effective. We also provide additional evidence for the specificity of our anti-PlGF antibody and experiments to suggest that anti-PlGF treatment will not be effective for all tumors and why. Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies.

Place, publisher, year, edition, pages
2010. Vol. 141, no 1, 178-190 p.
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Medical Genetics
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URN: urn:nbn:se:uu:diva-123741DOI: 10.1016/j.cell.2010.02.039ISI: 000276211100022PubMedID: 20371353OAI: oai:DiVA.org:uu-123741DiVA: diva2:315623
Available from: 2010-04-29 Created: 2010-04-29 Last updated: 2010-12-22Bibliographically approved

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Claesson-Welsh, Lena

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