uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Show others and affiliations
1998 (English)In: Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, E-ISSN 1554-6578, Vol. 57, no 9, 874-882 p.Article in journal (Refereed) Published
Abstract [en]

Vascular endothelial growth factor (VEGF) is a known endothelial mitogen and a potent enhancer of vascular permeability although its role in focal cerebral ischemia is still not completely understood. The present report describes the immunohistochemical distribution of VEGF and its 2 receptors, Flt-1 and Flk-1 at day 1 and 3 following permanent and transient middle cerebral artery occlusion (MCAO) in the rat. A bilateral increase in VEGF immunoreactivity, particularly in neurons and blood vessels, was seen in both the experimental designs by day 1. By day 3, the immunoreactivity was restricted chiefly to the lesion side, where reaction was most prominent in the border zones of the infarcts. Immunoreaction to VEGF was more pronounced in cases of permanent MCAO than in transient MCAO. Flt-1 reaction was increased in neurons, glial and endothelial cells after both transient and permanent MCAO. Immunoreactivity to Flk-1 was prominent in glial cells and was present to some extent in endothelial cells. These findings indicate an early upregulation of VEGF and its receptors after permanent as well as transient focal cerebral ischemia in the rat.

Place, publisher, year, edition, pages
1998. Vol. 57, no 9, 874-882 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-124029PubMedID: 9737551OAI: oai:DiVA.org:uu-124029DiVA: diva2:317090
Available from: 2010-05-03 Created: 2010-05-03 Last updated: 2015-06-10Bibliographically approved

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Lennmyr, Fredrik
By organisation
Anaesthesiology and Intensive CareInternal Medicine
In the same journal
Journal of Neuropathology and Experimental Neurology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 206 hits
ReferencesLink to record
Permanent link

Direct link