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Brachial artery hyperemic blood flow velocities are related to carotid atherosclerosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine. (PIVUS)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine. (PIVUS)
2009 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 29, no 5, 360-365 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Cardiovascular (CV) risk relates to the blood flow velocity pattern in the brachial artery during hyperemia, especially to the hyperaemic systolic to diastolic mean blood flow velocity (SDFV) ratio. Here, we investigated the relations between SDFV in the brachial artery and different characteristics of carotid atherosclerosis. MATERIAL AND METHODS: Data were collected from 1016 70-year-olds participating in the Prospective Investigation of Uppsala Seniors study. Doppler recordings of blood flow velocity during hyperemia were analysed in the brachial artery. In the carotid artery, intima-media thickness (IMT) was recorded together with an assessment of echogenicity by the Grey scale median (GSM) method in both overt plaques and in the intima-media complex (IM-GSM). RESULTS: The SDFV ratio was related to the number of carotid arteries affected by plaque (P = 0.018) and inversely to plaque echogenicity (P = 0.0003). The SDFV ratio was also related to IMT (P = 0.0022) and inversely to IM-GSM (P = 0.0001). These relations were statistically significant also after adjusting for major CV risk factors, individually as well as summarised as the Framingham risk score. CONCLUSION: Our results indicate that the hyperemic systolic to diastolic blood flow velocity ratio in the brachial artery is related to atherosclerosis in the carotid artery.

Place, publisher, year, edition, pages
2009. Vol. 29, no 5, 360-365 p.
Keyword [en]
carotid atherosclerosis brachial velocity hyperemia
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-124222DOI: 10.1111/j.1475-097X.2009.00879.xISI: 000268981800007PubMedID: 19508277OAI: oai:DiVA.org:uu-124222DiVA: diva2:317246
Projects
PIVUS
Available from: 2010-05-03 Created: 2010-05-03 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Hyperemic Brachial Artery Blood Flow Velocity
Open this publication in new window or tab >>Hyperemic Brachial Artery Blood Flow Velocity
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis aims to evaluate the blood flow velocity in the Brachial artery during reactive hyperemia. Primarily to appraise the information it might contain regarding cardiovascular function and cardiovascular risk.

Ultrasonographic doppler measurements of the Brachial artery were made on the 1016 men and women aged 70 included in the prospective investigation of the vasculature in Uppsala seniors (PIVUS) study. Analysis of the blood flow velocity in the forearm was made in comparison to established methods of estimating endothelial function, clinical markers of cardiovascular risk, the Framingham risk score and global atherosclerosis determined by whole body magnetic resonance angiography.

Systolic blood flow velocity was positively related to cardiovascular risk whereas the diastolic velocity was inversely correlated. However, the systolic to diastolic blood flow velocity (SDFV) ratio was more closely associated with cardiovascular risk than its components apart.

Ultrasonographic markers of Carotid atherosclerosis were related to the SDFV ratio. Concentric left ventricular remodeling and left ventricular mass index were also associated with the SDFV ratio, but not to its numerator or denominator separately. A similar pattern was found when assessing SDFV ratio in relation to global atherosclerosis, as well as to established markers of arterial compliance and vasodilation.

In conclusion, during reactive hyperemia of the Brachial artery, the systolic to diastolic blood flow velocity ratio appears to contain information of additional value than its components separately, independently of established cardiovascular risk factors. Possibly, the SDFV ratio could offer a promising means to estimate cardiovascular risk in aging populations.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2010. 79 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 620
National Category
Medical and Health Sciences Cardiac and Cardiovascular Systems
Research subject
Medical Science
Identifiers
urn:nbn:se:uu:diva-132918 (URN)978-91-554-7942-8 (ISBN)
Public defence
2010-12-15, Enghoffsalen, Ingång 50, Akademiska Sjukhuset, Uppsala, 09:15 (Swedish)
Opponent
Supervisors
Projects
PIVUS
Available from: 2010-11-24 Created: 2010-10-28 Last updated: 2011-01-13Bibliographically approved

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Järhult, Susann J.

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