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Complement activation in Lyme neuroborreliosis: increased levels of C1q and C3a in cerebrospinal fluid indicate complement activation in the CNS
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2007 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 183, no 1-2, 200-207 p.Article in journal (Refereed) Published
Abstract [en]

A strong initial inflammatory response is important in neuroborreliosis. Since complement is a main player in early inflammation, we monitored the concentration and activation of complement in plasma and cerebrospinal fluid from 298 patients, of whom 23 were diagnosed with neuroborreliosis. Using sandwich ELISAs, we found significantly elevated levels of C1q, C4, C3, and C3a in cerebrospinal fluid, but not in plasma, in patients with neuroborreliosis. This finding indicates that complement plays a role in the human immune response in neuroborreliosis, that the immunologic process is compartmentalized to the CNS, and that complement activation may occur via the classical pathway.

Place, publisher, year, edition, pages
2007. Vol. 183, no 1-2, 200-207 p.
Keyword [en]
Complement, Neuroborreliosis, Inflammation, Lyme borreliosis, Cerebrospinal fluid
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-124309DOI: 10.1016/j.jneuroim.2006.10.022ISI: 000244773000024PubMedID: 17157926OAI: oai:DiVA.org:uu-124309DiVA: diva2:317318
Available from: 2010-05-04 Created: 2010-05-03 Last updated: 2011-04-07Bibliographically approved

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