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Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology.
2010 (English)In: Trends in immunology, ISSN 1471-4906, E-ISSN 1471-4981, Vol. 31, no 1, 32-38 p.Article, review/survey (Refereed) Published
Abstract [en]

Biomaterials (e.g. polymers, metals, or ceramics), cell and cell cluster (e.g. pancreatic islets) transplantation are beginning to offer novel treatment modalities for some otherwise intractable diseases. The innate immune system is involved in incompatibility reactions that occur when biomaterials or cells are introduced into the blood circulation. In particular, the complement, coagulation and contact systems are involved in the recognition of biomaterials and cells, eliciting activation of platelets and leukocytes. Such treatments are associated with anaphylactoid and thrombotic reactions, inflammation, and rejection of biomaterials and cells, leading to treatment failures and adverse reactions. We discuss here the new technologies that are being developed to shield the biomaterial and cell surfaces from recognition by the innate immune system.

Place, publisher, year, edition, pages
2010. Vol. 31, no 1, 32-38 p.
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Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-124312DOI: 10.1016/j.it.2009.09.005ISI: 000274555200005PubMedID: 19836998OAI: oai:DiVA.org:uu-124312DiVA: diva2:317331
Available from: 2010-05-03 Created: 2010-05-03 Last updated: 2017-12-12Bibliographically approved

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Nilsson, BoKorsgren, OlleEkdahl, Kristina Nilsson

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