The long and the short of it: RNA-directed chromatin asymmetry in mammalian X-chromosome inactivation
2009 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 583, no 5, 857-864 p.Article, review/survey (Refereed) Published
Mammalian X-chromosome inactivation is controlled by a multilayered silencing pathway involving both short and long non-coding RNAs, which differentially recruit the epigenetic machinery to establish chromatin asymmetries. In response to developmentally regulated small RNAs, dicer, a key effector of RNA interference, locally silences Xist on the active X-chromosome and establishes the heterochromatin conformation along the silent X-chromosome. The 1.6 kb RepA RNA initiates silencing by targeting the PRC2 polycomb complex to the inactive X-chromosome. In addition, the nuclear microenvironment is implicated in the initiation and maintenance of X-chromosome asymmetries. Here we review new findings involving these various RNA species in terms of understanding Xist gene regulation and the establishment of X-chromosome inactivation.
Place, publisher, year, edition, pages
2009. Vol. 583, no 5, 857-864 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-124431DOI: 10.1016/j.febslet.2009.02.004ISI: 000264475600001PubMedID: 19302783OAI: oai:DiVA.org:uu-124431DiVA: diva2:317538