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Myeloperoxidase is not useful for the early assessment of patients with chest pain
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (UCR)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (UCR)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (UCR)
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2010 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 43, no 3, 240-245 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Myeloperoxidase (MPO) has been listed as a potentially useful risk marker in acute coronary syndrome. However, its clinical utility in patients with acute chest pain is not yet defined. DESIGN AND METHODS: MPO (Architect, Abbott Diagnostics) was measured in 120 healthy controls and 303 chest pain patients who had been admitted to the coronary care units of three Swedish hospitals. RESULTS: Chest pain patents had significantly higher median MPO levels compared to healthy controls (120.6 vs. 78. 9 pmol/L; p<0.001). However, MPO was not useful for the diagnosis of myocardial infarction (c-statistics 0.61 [95% CI 0.54-0.67]), and Cox regression analysis revealed no independent association between MPO and mortality (adjusted hazard ratio 1.3 [95% CI 0.8-2.0]) or the composite endpoint (adjusted hazard ratio 1.1 [95% CI 0.8-1.5]) after a median follow-up of 4.9 years. CONCLUSIONS: MPO provided no clinically relevant information in the present population of chest pain patients.

Place, publisher, year, edition, pages
2010. Vol. 43, no 3, 240-245 p.
Keyword [en]
Myeloperoxidase, Acute chest pain, Risk prediction, Prognosis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-124530DOI: 10.1016/j.clinbiochem.2009.09.026ISI: 000274104000004PubMedID: 19822136OAI: oai:DiVA.org:uu-124530DiVA: diva2:317643
Available from: 2010-05-04 Created: 2010-05-04 Last updated: 2017-12-12Bibliographically approved

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Eggers, Kai M.Johnston, NinaOldgren, JonasLindahl, Bertil

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