Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action
2009 (English)In: Endocrine (Basingstoke), ISSN 1355-008X, Vol. 35, no 3, 312-324 p.Article in journal (Refereed) Published
Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-terminal amino acid residue sequence, RF(Y) amide, a sequence distinct from that required for melanocortin receptor binding. A recently delineated family of RFamide receptors recognizes both of these C-terminal motifs. We now present evidence that an antagonist with Y1 and RFamide receptor activity, BIBO3304, will attenuate the central cardiovascular effects of both gamma-melanocyte stimulating hormone (gamma-MSH) and NPY. The use of synthetic melanocortin and NPY peptide analogs excluded an interaction with melanocortin or Y family receptors. We suggest that the anatomical convergence of NPY and melanocortin neurons on cardiovascular control centers may have pathophysiological implications through a common or similar RFamide receptor(s), much as they converge on other nuclei to coordinately control energy homeostasis.
Place, publisher, year, edition, pages
2009. Vol. 35, no 3, 312-324 p.
gamma-MSH, Neuropeptide Y, Hypertensive effects, Central nervous system, RFamide peptides, RFamide receptors, Y1 antagonists, Central vasopressin system
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-123964DOI: 10.1007/s12020-008-9141-3ISI: 000266476500008PubMedID: 19363600OAI: oai:DiVA.org:uu-123964DiVA: diva2:317701